基因名：
FNTA
产品别名：
FPTA； PGGT1A； PTAR2； FNTA； farnesyltransferase, CAAX box, alpha； farnesyltransferase, CAAX box, alpha； protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha； FTase-alpha； GGTase-I-alpha； farnesyl-protein transferase alpha-subunit； protein prenyltransferase alpha subunit repeat containing 2； ras proteins prenyltransferase subunit alpha； type I protein geranyl-geranyltransferase alpha subunit； 法尼基转移酶α(FNTa)； 蛋白香叶烯基转移酶1α；
背景信息：
FNTA, also known as CAAX farnesyltransferase (FTase), attaches a farnesyl group from farnesyl pyrophosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the so-called CAAX box, where C is cysteine, A is usually but not always an aliphatic amino acid, and X is typically methionine or serine. This type of posttranslational modification provides a mechanism for membrane localization of proteins that lack a transmembrane domain. This enzyme has the remarkable property of farnesylating peptides as short as four residues in length that conform to the CAAX consensus sequence. FNTA is also a specific cytoplasmic interactor of the transforming growth factor-beta and activin type I receptors. It is likely to be a key component of the signaling pathway which involves p21ras, an important substrate for farnesyltransferase.
