基因名:
FOLR2
产品别名:
BETA-HFR; FBP; FBP/PL-1; FOLR1; FR-BETA; FR-P3; FRbeta; FOLR2; folate receptor beta; folate receptor beta; folate receptor beta; folate receptor 2 (fetal); folate receptor alpha; folate receptor, fetal/placental; folate-binding protein, fetal/placental; placental folate-binding protein; 胎盘叶酸受体蛋白2;
背景信息:
FOLR1 and FOLR2 are equipped with cellular glycosylphosphatidylinositol (GPI) anchors. FOLR1 is secreted from epithelia with or without a micelle-encapsulated GPI-anchor into milk and other body fluids/secretions, e.g. semen where its interaction with spermatozoa indicates a role in male fertility. FOLR1 and FOLR2 serve as serum biomarkers of various diseases. FOLR3 possesses no GPI-anchor and originates from secretory granules of neutrophil granulocytes; its concentration in serum correlates to the FOLR3 content in leukocytes and rises with increased leukocyte counts (infection, malignancy and pregnancy).