基因名：
FOSL2
产品别名：
FRA2； FOSL2； FOS like 2, AP-1 transcription factor subunit； FOS like 2, AP-1 transcription factor subunit； fos-related antigen 2； FOS like 2, AP-1 trancription factor subunit； FOS like antigen 2； FRA-2； fos相关抗原2；
背景信息：
Fos and Jun dimerize to form Activator Protein 1 (AP1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13 acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the 'leucine-zipper' motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own. The various dimers differ in their ability to transactivate AP1 dependent genes.
