基因名：
FPR2
产品别名：
ALX； ALXR； FMLP-R-II； FMLPX； FPR2A； FPRH1； FPRH2； FPRL1； HM63； LXA4R； FPR2； formyl peptide receptor 2； formyl peptide receptor 2； N-formyl peptide receptor 2； FMLP-R-I； FMLP-related receptor I； LXA4 receptor； RFP； formyl peptide receptor-like 1； lipoxin A4 receptor (formyl peptide receptor related)； 甲酰肽受体2(FPR2)； 脂氧素受体1；
背景信息：
FPRL1 is a low affinity receptor to N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4). FPRL1 has been reported in phagocytes, monocytes, neutrophils, differentiated myeloid cells from bone marrow, granulocyte HL-60 cells, and synovial fibroblasts. ESTs have been isolated from blood, leukocyte, lung, and placenta libraries.
