基因名：
MTOR
产品别名：
FRAP； FRAP1； FRAP2； RAFT1； RAPT1； SKS； MTOR； mechanistic target of rapamycin kinase； mechanistic target of rapamycin kinase； serine/threonine-protein kinase mTOR； FK506 binding protein 12-rapamycin associated protein 2； FK506-binding protein 12-rapamycin complex-associated protein 1； FKBP-rapamycin associated protein； FKBP12-rapamycin complex-associated protein 1； mammalian target of rapamycin； mechanistic target of rapamycin (serine/threonine kinase)； rapamycin and FKBP12 target 1； rapamycin associated protein FRAP2； rapamycin target protein 1； 哺乳动物雷帕霉素靶蛋白(mTOR)； 磷酸化雷帕霉素靶蛋白； 雷帕霉素靶蛋白；
背景信息：
mTOR is one of a family of proteins involved in cell cycle progression, DNA recombination, and DNA damage detection. In rat, it is a 289-kDa protein (symbolized RAFT1) with significant homology to the Saccharomyces cerevisiae protein TOR1 and has been shown to associate with the immunophilin FKBP12 in a rapamycin dependent fashion. The FKBP12-rapamycin complex is known to inhibit progression through the G1 cell cycle stage by interfering with mitogenic signaling pathways involved in G1 progression in several cell types, as well as in yeast. The binding of FRAP to FKBP12-rapamycin correlated with the ability of these ligands to inhibit cell cycle progression.
