基因名:
FUS
产品别名:
ALS6; ETM4; FUS1; HNRNPP2; POMP75; TLS; altFUS; FUS; FUS RNA binding protein; FUS RNA binding protein; RNA-binding protein FUS; 75 kDa DNA-pairing protein; fus-like protein; fused in sarcoma; fusion gene in myxoid liposarcoma; heterogeneous nuclear ribonucleoprotein P2; oncogene FUS; oncogene TLS; translocated in liposarcoma protein; 粘液样脂肪肉瘤蛋白FUS1; 融合蛋白(FUS);
背景信息:
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq].