基因名：
GALE
产品别名：
SDR1E1； GALE； UDP-galactose-4-epimerase； UDP-galactose-4-epimerase； UDP-glucose 4-epimerase； UDP galactose-4'-epimerase； UDP-GalNAc 4-epimerase； UDP-GlcNAc 4-epimerase； UDP-N-acetylgalactosamine 4-epimerase； UDP-N-acetylglucosamine 4-epimerase； epididymis secretory sperm binding protein； galactose-4-epimerase, UDP-； galactowaldenase； short chain dehydrogenase/reductase family 1E, member 1； 半乳糖瓦尔登转化酶；
背景信息：
The enzyme UDP-Glucose 4-Epimerase (GALE) is a homodimeric epimerase found in bacterial, plant and mammalian cells. UDP-Glucose 4-Epimerase performs the final step in the Leloir pathway of Galactose metabolism, it catalyzes two distinct but analogous reactions: the epimerization of UDP-Gglucose to UDP-Galactose and the epimerization of UDP-N-Acetylglucosamine to UDP-N-Acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids.
