基因名：
LRRC32
产品别名：
CPPRDD； D11S833E； GARP； LRRC32； leucine rich repeat containing 32； leucine rich repeat containing 32； transforming growth factor beta activator LRRC32； garpin； glycoprotein A repetitions predominant； leucine-rich repeat-containing protein 32； 含亮氨酸丰富重复蛋白32(LRRC32)； 富含亮氨酸重复蛋白32；
背景信息：
Leucine Rich Repeat Containing 32 (LRRC32), also known as Glycoprotein A Repetitions Predominant (GARP), has been postulated as a novel surface marker of activated T(regs). LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells. The presentation of TGF-beta on Tregs contributes to their ability to suppress naive T cell proliferation. LRRC32 is widely expressed during embryogenesis and on adult platelets. Human LRRC32 is identified as a lineage specific key receptor for human T cells.
