基因名：
GBP1
产品别名：
GBP1； guanylate binding protein 1； guanylate binding protein 1； guanylate-binding protein 1； GBP-1； GTP-binding protein 1； guanine nucleotide-binding protein 1； guanylate binding protein 1, interferon-inducible, 67kDa； huGBP-1； interferon-induced guanylate-binding protein 1； G蛋白结合蛋白1； 干扰素诱导鸟苷酸结合蛋白1(GBP1)；
背景信息：
Guanylate-binding proteins, GBP1 and GBP2 are GTP-binding proteins with a high-turnover GTPase activity and an antiviral effect (1-4). GBP1 mediates an antiviral effect against vesicular stomatitis virus and encephalomyocarditis virus and plays a role in the IFN-mediated antiviral response against these viruses (4). GBP1 and GBP2 belong to a group of large GTP-binding proteins with a high concentration-dependent GTPase activity that have the common ability to undergo oligomerization (1). GBP1 and GBP2 are bone marrow-derived GTPases encoded by interferon-activated genes and are inducible following IFN treatment (2,3). Specifically, GBP1 is expressed in cultured mammary epithelial tumor cell lines after treatment with IFN-gamma and LPS.
