基因名：
GDI1
产品别名：
1A； GDIL； MRX41； MRX48； OPHN2； RABGD1A； RABGDIA； XAP-4； XLID41； GDI1； GDP dissociation inhibitor 1； GDP dissociation inhibitor 1； rab GDP dissociation inhibitor alpha； GDI-1； guanosine diphosphate dissociation inhibitor 1； oligophrenin-2； protein XAP-4； rab GDI alpha； rab GDP-dissociation inhibitor, alpha； testis secretory sperm-binding protein Li 208a； GDP解离抑制因子1(GDI1)； 精神发育迟滞相关蛋白Rab GDIα；
背景信息：
Rab proteins, a family of Ras-related small GTP-binding proteins, play a key role in regulating intracellular vesicle trafficking (1?). Rab GDP dissociation inhibitor (Rab GDI or GDI2) forms a soluble complex with Rab proteins and thereby prevents the exchange of GDP for GTP (1?). In mammals, there exist two major isoforms, Rab GDI alpha (also known as XAP-4) and Rab GDI beta (1,4). While the mammalian Rab GDI beta-genes are ubiquitously expressed, the Rab GDI ?genes are predominantly brain-specific (1). Since it is expressed predominantly in neural and sensory tissues, Rab GDI a may serve a specific function in neural signal transmission (5). The gene sequences for the Rab GDI proteins are extremely conserved in evolution, with substantial homology preserved across three eukaryotic kingdoms (5).
