基因名：
GFI1
产品别名：
GFI-1； GFI1A； SCN2； ZNF163； GFI1； growth factor independent 1 transcriptional repressor； growth factor independent 1 transcriptional repressor； zinc finger protein Gfi-1； growth factor independence-1； growth factor independent 1 transcription repressor； growth factor independent protein 1； zinc finger protein 163； 自主生长因子GFI1；
背景信息：
Growth factor independent 1 (Gfi-1) is a transcriptional repressor that specifically binds to the DNA consensus sequence TAAATCAC(A/T)GCA. The carboxy-terminus of Gfi-1 contains six C2H2-type zinc finger motifs, and zinc fingers 3, 4 and 5 are required for the binding of Gfi-1 to its DNA binding site. Gfi-1 also contains a 20 amino acid SNAG domain which mediates transcriptional repression. It represses Bax at the mRNA and protein levels, resulting in the inhibition of cell death. Gfi1 is expressed outside the lymphoid system in granulocytes and activated macrophages. Gfi-1B, a related protein, is a transcriptional repressor primarily expressed in bone marrow and spleen. Gfi-1B is a direct repressor of the p21 promoter and the Socs 1 and 3 promoters. The genes encoding human Gfi-1 and Gfi-1B map to chromosome 1p22 and 9q34.3, respectively.
