基因名：
GFRA2
产品别名：
GDNFRB； NRTNR-ALPHA； NTNRA； RETL2； TRNR2； GFRA2； GDNF family receptor alpha 2； GDNF family receptor alpha 2； GDNF family receptor alpha-2； GDNF receptor beta； GDNFR-alpha-2； GDNFR-beta； GFR-alpha 2； NTNR-alpha； PI-linked cell-surface accessory protein； RET ligand 2； TGF-beta-related neurotrophic factor receptor 2； TRN receptor, GPI-anchored； glial cell line derived neurotrophic factor receptor, beta； neurturin receptor alpha； 胶质细胞系来源神经营养因子受体α2(GFRa2)； 胶质细胞系来源神经营养因子受体α2(GFRa2)真核蛋白； 胶质细胞系源性神经营养因子受体α2；
背景信息：
GDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It also able to mediate GDNF signaling through the RET tyrosine kinase receptor. It acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1.
