基因名：
GNB3
产品别名：
CSNB1H； HG2D； GNB3； G protein subunit beta 3； G protein subunit beta 3； guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3； G protein, beta-3 subunit； GTP-binding regulatory protein beta-3 chain； guanine nucleotide binding protein (G protein), beta polypeptide 3； guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3； heterotrimeric guanine nucleotide-binding protein 2D； hypertension associated protein； transducin beta chain 3； G蛋白β3+O16328；
背景信息：
G proteins are composed of 3 units, alpha, beta and gamma and are involved in the modulation and transduction of various transmembrane signalling systems. There are families of related genes for each subunit. GNB3 encodes a beta subunit. Beta subunits are required for GTPase activity, for replacement of GDP by GTP, regulate alpha subunits and for G protein-effector interactions. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity and is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity.
