基因名：
GRB2
产品别名：
ASH； EGFRBP-GRB2； Grb3-3； MST084； MSTP084； NCKAP2； GRB2； growth factor receptor bound protein 2； growth factor receptor bound protein 2； growth factor receptor-bound protein 2； HT027； SH2/SH3 adapter GRB2； abundant SRC homology； epidermal growth factor receptor-binding protein GRB2； epididymis secretory sperm binding protein； growth factor receptor-bound protein 3； protein Ash； 生长因子受体结合蛋白2； 生长因子受体结合蛋白2(Grb2)； 生长因子受体结合蛋白2(Grb2)真核蛋白；
背景信息：
As an adaptor protein, Growth Factor Receptor-Bound Protein 2 (GRB2) is involved in siganl transduction and consists of a central SH2 domain flanked by two SH3 domains. GRB2 associates with activated Tyr-phosphorylated EGF receptor/EGFR and PDGF receptors via its SH2 domain, stimulating GTP binding to Ras, which in turn activates MAPK and other signaling pathway.It also associates to other cellular Tyr-phosphorylated proteins such as SIT1, IRS1, IRS4, SHC and LNK. probably via the concerted action of both its SH2 and SH3 domains.
