基因名：
GRINA
产品别名：
HNRGW； LFG1； NMDARA1； TMBIM3； GRINA； glutamate ionotropic receptor NMDA type subunit associated protein 1； glutamate ionotropic receptor NMDA type subunit associated protein 1； protein lifeguard 1； NMDA receptor glutamate-binding subunit； glutamate [NMDA] receptor-associated protein 1； glutamate receptor, NMDA subtype, glutamate-binding subunit； glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)； lifeguard 1； putative MAPK-activating protein PM02； transmembrane BAX inhibitor motif containing 3； transmembrane BAX inhibitor motif-containing protein 3； 谷氨酸受体相关蛋白1；
背景信息：
Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Synaptic and extrasynaptic NMDA receptors have been shown to have opposite effects on neuronal survival, CREB function and gene regulation. As one of the four major proteins of the NMDA receptor ion channel, GRINA (Glutamate [NMDA] receptor-associated protein 1), also designated NMDA receptor glutamate-binding subunit or putative MAPK-activating protein PM02, is a 371 amino acid multi-pass transmembrane protein. Due to the chromosomal location of the gene encoding GRINA, studies have linked possible GRINA involvement with a form of idiopathic generalized epilepsy.
