基因名：
HGF
产品别名：
DFNB39； F-TCF； HGFB； HPTA； SF； HGF； hepatocyte growth factor； hepatocyte growth factor； hepatocyte growth factor； fibroblast-derived tumor cytotoxic factor； hepatocyte growth factor (hepapoietin A; scatter factor)； hepatopoietin-A； lung fibroblast-derived mitogen； 肝细胞生长因子(HGF)； 肝细胞生长因子α； 肝细胞生长因子β；
背景信息：
Hepatocyte growth factor/scatter factor (HGF/SF) is a paracrine cellular growth, motility and morphogenic factor. It belongs to the peptidase S1 family and Plasminogen subfamily, contains 4 kringle domains, 1 PAN domain and 1 peptidase S1 domain. HGF regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. HGF is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration.
