基因名:
HLA-A
产品别名:
HLAA; HLA-A; major histocompatibility complex, class I, A; major histocompatibility complex, class I, A; HLA class I histocompatibility antigen, A alpha chain; HLA class I histocompatibility antigen, A-1 alpha chain; MHC class I antigen HLA-A heavy chain; leukocyte antigen class I-A; Ⅰ类主要组织相容性复合体A(MHCA); 白细胞抗原A; 组织相容性复合体蛋白1; 组织相容性复合物1A1; 组织相容性复合物A2;
背景信息:
MHC Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. MHC class I antigens are heterodimers consisting of one alpha chain (44kDa) with beta 2 microglobulin (11.5 kDa). The antigen is expressed by all somatic cells at varying levels. MHC Class I molecules are expressed on most nucleated cells where they present endogenously synthesized antigenic peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. Fibroblasts or neurons however only show a low level of antigen.