基因名：
HLA-E
产品别名：
HLA-6.2； QA1； HLA-E； major histocompatibility complex, class I, E； major histocompatibility complex, class I, E； HLA class I histocompatibility antigen, alpha chain E； MHC class I antigen E； MHC class Ib antigen； Ⅰ类主要组织相容性复合体E(MHCE)； 白细胞抗原E； 白细胞抗原E蛋白；
背景信息：
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008]
