基因名：
HMGB1
产品别名：
HMG-1； HMG1； HMG3； SBP-1； HMGB1； high mobility group box 1； high mobility group box 1； high mobility group protein B1； Amphoterin； Sulfoglucuronyl carbohydrate binding protein； high-mobility group (nonhistone chromosomal) protein 1； HMGB1蛋白； 高迁移率族蛋白1(HMGB1)； 高迁移率族蛋白1(HMGB1)真核蛋白； 高迁移率族蛋白B1；
背景信息：
High mobility group protein B1 is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3.It Contains 2 HMG box DNA-binding domains entitled box A and box B and It is a highly negative-charged C terminus. As a nuclear protein, HMGB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription which is essential for individual survival. Meanwhile, it is revealed that HMGB1 can also act as a cytokine extracellularlly and regulates monocyte, T cell, dendritic cell activities in inflammatory responses.
