基因名：
HMGA1
产品别名：
HMG-R； HMGA1A； HMGIY； HMGA1； high mobility group AT-hook 1； high mobility group AT-hook 1； high mobility group protein HMG-I/HMG-Y； high mobility group protein A1； high mobility group protein R； nonhistone chromosomal high-mobility group protein HMG-I/HMG-Y； 高迁移率族AT Hook蛋白1(HMGA1)； 高迁移率族蛋白A1；
背景信息：
HMGA1 (HMGI/Y; high mobility group AT-hook 1) is a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. There are two splice isoforms of HMGA1 - the full length HMGA1a/HMGI and the shortened form HMGA1b/HMGY. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. HMGA1 is frequently acetylated and is found in the nucleus. Interacts with HIV-1 pre-integration complex.
