基因名：
HPGD
产品别名：
15-PGDH； PGDH； PGDH1； PHOAR1； SDR36C1； HPGD； 15-hydroxyprostaglandin dehydrogenase； 15-hydroxyprostaglandin dehydrogenase； 15-hydroxyprostaglandin dehydrogenase [NAD(+)]； 15-hydroxyprostaglandin dehydrogenase (NAD(+))； NAD+-dependent 15-hydroxyprostaglandin dehydrogenase； eicosanoid/docosanoid dehydrogenase； hydroxyprostaglandin dehydrogenase 15-(NAD)； prostaglandin dehydrogenase 1； short chain dehydrogenase/reductase family 36C member 1； 前列腺素脱氢酶1；
背景信息：
15-hydroxyprostaglandin dehydrogenase [NAD(+)], also known as Prostaglandin dehydrogenase 1, 15-PGDH, HPGD and PGDH1, belongs to the short-chain dehydrogenases/reductases (SDR) family. HPGD localizes to the cytoplasm and can be found in colon epithelium, existing as a homodimer. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. HPGD is down-regulated by cortisol, dexamethasone and betamethasone, up-regulated by TGFB1. HPGD inhibits in vivo proliferation of colon cancer cells. HPGD is the key enzyme for the inactivation of prostaglandins, and thus regulates processes such as inflammation or proliferation.
