基因名：
IDH2
产品别名：
D2HGA2； ICD-M； IDH； IDH-2； IDHM； IDP； IDPM； mNADP-IDH； IDH2； isocitrate dehydrogenase (NADP(+)) 2； isocitrate dehydrogenase (NADP(+)) 2； isocitrate dehydrogenase [NADP], mitochondrial； NADP(+)-specific ICDH； isocitrate dehydrogenase (NADP(+)) 2, mitochondrial； isocitrate dehydrogenase 2 (NADP+), mitochondrial； oxalosuccinate decarboxylase； 异柠檬酸脱氢酶2(IDH2)； 线粒体异柠檬酸脱氢酶；
背景信息：
IDH2 (isocitrate dehydrogenase 2 (NADP+), mitochondrial), also designated NADP+-specific ICDH; isocitrate dehydrogenase, mitochondrial; and oxalosuccinate decarboxylase, is a 452 amino acid enzyme encoded by the human gene IDH2. IDH2 belongs to the isocitrate and isopropylmalate dehydrogenases family and contains two nucleotide binding regions. IDH2 is involved in the reduction of NADP+ to NADPH and maintains the supply of glutathione (GSH) in mitochondria. It is believed to play a role in intermediary metabolism and energy production. IDH2 also tightly associates with the pyruvate dehydrogenase complex. IDH2 is found in the mitochondrion as a homodimer and can bind one magnesium or manganese ion per subunit.
