基因名：
IDH3A
产品别名：
RP90； IDH3A； isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha； isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha； isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial； H-IDH alpha； NAD(+)-specific ICDH subunit alpha； NAD(H)-specific isocitrate dehydrogenase alpha subunit； NAD+-specific ICDH； isocitrate dehydrogenase (NAD(+)) 3 alpha； isocitrate dehydrogenase (NAD+) alpha chain； isocitrate dehydrogenase 3 (NAD(+)) alpha； isocitrate dehydrogenase 3 (NAD+) alpha； isocitric dehydrogenase subunit alpha； 草酰琥珀酸脱羧酶α；
背景信息：
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. IDH3A is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase.
