基因名：
IDH3G
产品别名：
H-IDHG； IDH3G； isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma； isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma； isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial； IDH-gamma； NAD (H)-specific isocitrate dehydrogenase gamma subunit； NAD(+)-specific ICDH subunit gamma； NAD+-specific ICDH； isocitrate dehydrogenase (NAD(+)) 3 gamma； isocitrate dehydrogenase 3 (NAD(+)) gamma； isocitrate dehydrogenase 3 (NAD+) gamma； isocitrate dehydrogenase 3 gamma； isocitrate dehydrogenase, NAD(+)-specific, mitochondrial, gamma subunit； isocitric dehydrogenase subunit gamma； 异柠檬酸脱氢酶gamma亚基；
背景信息：
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the gamma subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. This gene is a candidate gene for periventricular heterotopia. Several alternatively spliced transcript variants of this gene have been described, but only some of their full length natures have been determined. [provided by RefSeq, Jul 2008].
