基因名:
IDI1
产品别名:
IPP1; IPPI1; IDI1; isopentenyl-diphosphate delta isomerase 1; isopentenyl-diphosphate delta isomerase 1; isopentenyl-diphosphate Delta-isomerase 1; IPP isomerase 1; isopentenyl diphosphate dimethylallyl diphosphate isomerase 1; isopentenyl pyrophosphate isomerase 1; 异戊烯焦磷酸1;
背景信息:
IDI1 is a peroxisomally localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP). These are substrates for the reactions that ultimately result in the synthesis of cholesterol. There is reduction in IPP isomerase activity in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy.