基因名:
IL2RG
产品别名:
CD132; CIDX; IL-2RG; IMD4; P64; SCIDX; SCIDX1; IL2RG; interleukin 2 receptor subunit gamma; interleukin 2 receptor subunit gamma; cytokine receptor common subunit gamma; CD132 antigen; IL-2 receptor subunit gamma; IL-2R subunit gamma; common cytokine receptor gamma chain; gammaC; interleukin 2 receptor, gamma; nonfunctional common cytokine receptor gamma chain; 白介素2受体γ(IL2Rg); 白介素2受体γ链;
背景信息:
IL2RG contains one fibronectin type-III domain. IL2RG is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. IL2RG interacts with SHB upon interleukin stimulation and HTLV-1 accessory protein p12I. Defects in IL2RG are the cause of X-linked combined immunodeficiency (XCID) and severe combined immunodeficiency X-linked T-cell-negative /B-cell-positive / NK-cell-negative (XSCID).