基因名：
IL6ST
产品别名：
CD130； CDW130； GP130； HIES4； HIES4A； HIES4B； IL-6RB； IMD94； STWS2； sGP130； IL6ST； interleukin 6 cytokine family signal transducer； interleukin 6 cytokine family signal transducer； interleukin-6 receptor subunit beta； CD130 antigen； IL-6 receptor subunit beta； IL-6R subunit beta； gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form； gp130, oncostatin M receptor； interleukin receptor beta chain； interleukin-6 signal transducer； membrane glycoprotein 130； membrane glycoprotein gp130； oncostatin-M receptor subunit alpha； 白细胞介素6受体β/CD130； 白细胞介素6受体β蛋白； 磷酸化gp130； 糖蛋白130(gp130)； 糖蛋白130(gp130)真核蛋白；
背景信息：
CD130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.
