基因名：
IL10RB
产品别名：
CDW210B； CRF2-4； CRFB4； D21S58； D21S66； IL-10R2； IL-10RB； IL10RB； interleukin 10 receptor subunit beta； interleukin 10 receptor subunit beta； interleukin-10 receptor subunit beta； IL-10 receptor subunit beta； IL-10R subunit 2； IL-10R subunit beta； cytokine receptor class-II CRF2-4； cytokine receptor class-II member 4； cytokine receptor family 2 member 4； cytokine receptor family II, member 4； interleukin 10 receptor, beta； interleukin-10 receptor subunit 2； 白介素10受体β(IL10Rb)； 白细胞介素-10受体β；
背景信息：
Interleukin-10 receptor subunit beta(IL10RB), also known as Cytokine receptor class-II member 4,Cytokine receptor family 2 member 4,Interleukin-10 receptor subunit 2, belongs to the type II cytokine receptor family. IL10RB is a single- pass type I membrane protein and contains two fibronectin type-III domains. It is an accessory chain which is essential for the active interleukin 10 receptor complex. Coexpression of IL10RB and IL10RA proteins has been shown to be required for IL10-induced signal transduction. Defects in IL10RB are the cause of inflammatory bowel disease type 25 (IBD25) which is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology.
