基因名：
IRF4
产品别名：
LSIRF； MUM1； NF-EM5； SHEP8； IRF4； interferon regulatory factor 4； interferon regulatory factor 4； interferon regulatory factor 4； lymphocyte-specific interferon regulatory factor； multiple myeloma oncogene 1； 干扰素调节因子4； 干扰素调节因子4(IRF4)； 黑色素关联瘤抗原1(MUM1)；
背景信息：
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]
