基因名：
ITGA5
产品别名：
CD49e； FNRA； VLA-5； VLA5A； ITGA5； integrin subunit alpha 5； integrin subunit alpha 5； integrin alpha-5； CD49 antigen-like family member E； ITGA5/SLC9B1 fusion； fibronectin receptor subunit alpha； fibronectin receptor, alpha polypeptide； fibronectin receptor, alpha subunit； integrin alpha-F； integrin, alpha 5 (fibronectin receptor, alpha polypeptide)； very late activation protein 5, alpha subunit； Integrin alpha 5 beta 1(ITGA5&ITGB1)蛋白； 整合素α5； 整合素α5(ITGa5)；
背景信息：
Integrin α-5 belongs to the Integrin α chain family and contains 7 FG-GAP repeats. Integrin α-5 joins with Integrin-β1 to form a fibronectin and laminin receptor which recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. It is expressed on fibroblasts, endothelial cells, peripheral T cells and platelets. Integrin α-5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains. In addition to adhesion, ITGA5 participates in cell-surface mediated signalling.
