基因名：
ITGAL
产品别名：
CD11A； LFA-1； LFA1A； ITGAL； integrin subunit alpha L； integrin subunit alpha L； integrin alpha-L； CD11 antigen-like family member A； LFA-1 alpha； LFA-1A； antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide； integrin gene promoter； integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)； leukocyte adhesion glycoprotein LFA-1 alpha chain； leukocyte function-associated molecule 1 alpha chain； lymphocyte function-associated antigen 1, alpha polypeptide； 整合素αL； 淋巴细胞功能关联抗原1α(CD11a)；
背景信息：
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
