基因名：
ITGB2
产品别名：
CD18； LAD； LCAMB； LFA-1； MAC-1； MF17； MFI7； ITGB2； integrin subunit beta 2； integrin subunit beta 2； integrin beta-2； cell surface adhesion glycoprotein (LFA-1/CR3/P150,959 beta subunit precursor)； complement component 3 receptor 3 and 4 subunit； complement receptor C3 beta-subunit； integrin beta chain, beta 2； integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)； leukocyte cell adhesion molecule CD18； leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C； 整合素β2(CD18)； 整合素β2/ITGB2； 磷酸化整合素β2/Integrinβ2；
背景信息：
Enables amyloid-beta binding activity and complement component C3b binding activity. Contributes to cargo receptor activity. Involved in several processes, including cellular response to low-density lipoprotein particle stimulus; endocytosis; and positive regulation of leukocyte adhesion to vascular endothelial cell. Acts upstream of or within several processes, including activated T cell proliferation; integrin-mediated signaling pathway; and leukocyte migration. Located in external side of plasma membrane and membrane raft. Part of integrin alphaM-beta2 complex. Is expressed in several structures, including alimentary system; genitourinary system; heart and pericardium; hemolymphoid system; and nervous system. Used to study leukocyte adhesion deficiency 1 and psoriasis. Human ortholog(s) of this gene implicated in coronary restenosis; leukocyte adhesion deficiency; and leukocyte adhesion deficiency 1. Orthologous to human ITGB2 (integrin subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]
