基因名：
EIF6
产品别名：
CAB； EIF3A； ITGB4BP； b(2)gcn； eIF-6； p27(BBP)； p27BBP； EIF6； eukaryotic translation initiation factor 6； eukaryotic translation initiation factor 6； eukaryotic translation initiation factor 6； B4 integrin interactor； eukaryotic translation initiation factor 3A； p27 beta-4 integrin-binding protein； β4整合素结合蛋白； 真核翻译起始因子6(EIF6)；
背景信息：
Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by Intergrin beta 4 binding protein binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple transcript variants encoding several different isoforms have been found for this gene.
