重组NK细胞抑制性受体2DL1蛋白

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重组NK细胞抑制性受体2DL1蛋白

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

重组杀伤细胞免疫球蛋白样受体2DL1(KIR2DL1)
Recombinant KIR2DL1

基因名：

KIR2DL1

产品别名：

CD158A； KIR-K64； KIR221； KIR2DL3； NKAT； NKAT-1； NKAT1； p58.1； KIR2DL1； killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1； killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1； killer cell immunoglobulin-like receptor 2DL1； CD158 antigen-like family member A； KIR2DL protein； KIR2DL1/3DL2； MHC class I NK cell receptor； killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1； killer inhibitory receptor 2-2-1； natural killer-associated transcript 1； p58 NK cell inhibitory receptor NKR-K6； p58 NK receptor CL-42/47.11； p58 killer cell inhibitory receptor KIR-K64； p58 natural killer cell receptor clones CL-42/47.11； p58.1 MHC class-I-specific NK receptor； NK细胞抑制性受体2DL1；杀伤细胞免疫球蛋白样受体2DL1(KIR2DL1)；

背景信息：

Killer cell immunoglobulin-like receptor 2DL1 or KIR2DL1 is an inhibitory Natural Killer cell immunoglobulin-like receptor with two extracellular immunoglobulin domains. KIR2DL1 is a member of the Killer cell immunoglobulin-like receptor family whose members are classified by the number of the extracellular immunoglobulin domains and the length of the cytoplasm domain. KIR2DL1 is a transmembrane glycoprotein expressed by natural killer cells and subsets of T cells. KIR2DL1 down-regulates the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. It has been reported that the KIR2DL1 is bound to its class I MHC ligand, HLA-Cw4. The KIR2DL1-HLA-Cw4 interface exhibits charge and shape complementarity. Specificity is mediated by a pocket in KIR2DL1 that hosts the Lys80 residue of HLA-Cw4. Many residues conserved in HLA-C and KIR2DL receptors make different interactions in KIR2DL1-HLA-Cw4 and a previously reported KIR2DL2-HLA-Cw3 complex. A dimeric aggregate of KIR-HLA-C complexes was observed in one KIR2DL1-HLA-Cw4 crystal.

标签：His-tag
分类：Recombinant
类型：Protein
偶联物：Unconjugated
内毒素水平：按批次，参阅瓶身标签
性状:Liquid
浓度：Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型：purified
内含物：不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存：2-8°C不超过一个月，-80°C不超过12个月。避免反复冻融。
注意事项：仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。