基因名：
KIR2DL1
产品别名：
CD158A； KIR-K64； KIR221； KIR2DL3； NKAT； NKAT-1； NKAT1； p58.1； KIR2DL1； killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1； killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1； killer cell immunoglobulin-like receptor 2DL1； CD158 antigen-like family member A； KIR2DL protein； KIR2DL1/3DL2； MHC class I NK cell receptor； killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1； killer inhibitory receptor 2-2-1； natural killer-associated transcript 1； p58 NK cell inhibitory receptor NKR-K6； p58 NK receptor CL-42/47.11； p58 killer cell inhibitory receptor KIR-K64； p58 natural killer cell receptor clones CL-42/47.11； p58.1 MHC class-I-specific NK receptor； NK细胞抑制性受体2DL1； 杀伤细胞免疫球蛋白样受体2DL1(KIR2DL1)；
背景信息：
Killer cell immunoglobulin-like receptor 2DL1 or KIR2DL1 is an inhibitory Natural Killer cell immunoglobulin-like receptor with two extracellular immunoglobulin domains. KIR2DL1 is a member of the Killer cell immunoglobulin-like receptor family whose members are classified by the number of the extracellular immunoglobulin domains and the length of the cytoplasm domain. KIR2DL1 is a transmembrane glycoprotein expressed by natural killer cells and subsets of T cells. KIR2DL1 down-regulates the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. It has been reported that the KIR2DL1 is bound to its class I MHC ligand, HLA-Cw4. The KIR2DL1-HLA-Cw4 interface exhibits charge and shape complementarity. Specificity is mediated by a pocket in KIR2DL1 that hosts the Lys80 residue of HLA-Cw4. Many residues conserved in HLA-C and KIR2DL receptors make different interactions in KIR2DL1-HLA-Cw4 and a previously reported KIR2DL2-HLA-Cw3 complex. A dimeric aggregate of KIR-HLA-C complexes was observed in one KIR2DL1-HLA-Cw4 crystal.
