基因名：
KIR2DL4
产品别名：
CD158D； G9P； KIR-103AS； KIR-2DL4； KIR103； KIR103AS； KIR2DL4； killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4； killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4； killer cell immunoglobulin-like receptor 2DL4； CD158 antigen-like family member D； KIR2DL4 Killer-cell Immunoglobulin-like Receptor； KIR2DL4_00201； KIR2DL4_00201 protein； MHC class I NK cell receptor KIR103AS； killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4； killer cell inhibitory receptor 103AS； NK细胞抑制性受体2DL4（CD158D）；
背景信息：
Killer cell immunoglobulin-like receptor 2DL4(KIR2DL4) is a Single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains.It belongs to the immunoglobulin superfamily. KIR2DL4 is expressed in all NK cells and some T cells. KIR2DL4 activates the cytotoxicity of NK cells, despite the presence of an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytoplasmic tail. The ITIM was not necessary for activation of lysis by KIR2DL4. The activation signal of KIR2DL4 was sensitive to inhibition by another ITIM-containing receptor. The activation-deficient mutant of KIR2DL4 inhibited the signal delivered by the activating receptor CD16.
