基因名：
KLRB1
产品别名：
CD161； CLEC5B； NKR； NKR-P1； NKR-P1A； NKRP1A； hNKR-P1A； KLRB1； killer cell lectin like receptor B1； killer cell lectin like receptor B1； killer cell lectin-like receptor subfamily B member 1； C-type lectin domain family 5 member B； killer cell lectin-like receptor subfamily B, member 1； natural killer cell surface protein P1A； CD161分子(CD161)； NKR-P1C（NK1.1）；
背景信息：
Killer cell lectin-like receptor subfamily B, member 1(KLRB1) is a single-pass type II membrane protein which contains 1 C-type lectin domain. KLRB1 plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. It acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
