基因名：
LAMA3
产品别名：
BM600； E170； JEB2A； JEB2B； JEB2C； LAMNA； LOCS； LAMA3； laminin subunit alpha 3； laminin subunit alpha 3； laminin subunit alpha-3； BM600 150kD subunit； LAM3, alpha-3 subunit； epiligrin 170 kda subunit； epiligrin alpha 3 subunit； kalinin 165kD subunit； kalinin subunit alpha； laminin 5, alpha-3 subunit； laminin A3； laminin, alpha 3 (nicein (150kD), kalinin (165kD), BM600 (150kD), epilegrin)； laminin-5 alpha 3 chain； laminin-5 subunit alpha； laminin-6 subunit alpha； laminin-7 subunit alpha； nicein 150kD subunit； nicein subunit alpha； 层粘蛋白α3； 层粘连蛋白5； 层粘连蛋白α3(LAMa3)；
背景信息：
Laminins are basement membrane components thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminin 5 is an isoform composed of three distinct subunits, alpha 3, beta 3 and gamma 2, which are bound to each other in a cross-shaped molecule by disulphide bonds. It is a complex glycoprotein thought to be involved in cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes. It is also involved in signal transduction via tyrosine phosphorylation of pp125-FAK and p80, and differentiation of keratinocytes.
The laminin alpha 3 subunit is also thought to be a component of laminin 6 and laminin 7.
