基因名：
LBR
产品别名：
C14SR； DHCR14B； LMN2R； PHA； PHASK； TDRD18； LBR； lamin B receptor； lamin B receptor； delta(14)-sterol reductase LBR； 3-beta-hydroxysterol Delta (14)-reductase； C-14 sterol reductase； delta-14-SR； integral nuclear envelope inner membrane protein； sterol C14-reductase； tudor domain containing 18； 核纤层蛋白B受体；
背景信息：
Lamins are nuclear membrane proteins that serve to maintain specific cellular functions, such as DNA replication and chromatin organization. Lamin B receptor (LBR) is an integral protein of the nuclear envelope inner membrane. It is phosphorylated by CDC2 protein kinase in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures. The cleavage of lamins results in nuclear disregulation and cell death.
