基因名：
LCP2
产品别名：
IMD81； SLP-76； SLP76； LCP2； lymphocyte cytosolic protein 2； lymphocyte cytosolic protein 2； lymphocyte cytosolic protein 2； 76 kDa tyrosine phosphoprotein； SH2 domain-containing leukocyte protein of 76 kDa； SLP-76 tyrosine phosphoprotein； 淋巴细胞胞浆蛋白2(LCP2)； 磷酸化淋巴细胞胞浆蛋白2；
背景信息：
Lymphocyte cytosolic protein 2（LCP2）contains a SAM domain and a SH2 domain. It is highly expressed in spleen, thymus and peripheral blood leukocytes, T-cell and monocytic cell lines, but expressed at lower level in B-cell lines. LCP2 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. It is phosphorylated after T-cell receptor activation by ZAP70, ITK and TXK, which leads to the up-regulation of Th1 preferred cytokine IL-2 during post-translational modification. Studies using LCP2-deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.
