基因名:
LGALS9
产品别名:
HUAT; LGALS9A; LGALS9; galectin 9; galectin 9; galectin-9; ecalectin; gal-9; lectin, galactoside-binding, soluble, 9; tumor antigen HOM-HD-21; urate transporter/channel protein; Galectin 9蛋白; 半乳糖凝集素9; 半乳糖凝集素9(GAL9); 半乳糖凝集素9(GAL9)真核蛋白;
背景信息:
Galectin-9 is a cytoplasmic protein that contains two galectin domains. Galectin-9 is an S-type lectin that is over-expressed in Hodgkin's disease tissue. Galectin-9 binds galactosides and has high affinity for the Forssman pentasaccharide. Galectin-9 plays a role in thymocyte-epithelial interactions relevant to the biology of the thymus and Inhibits cell proliferation. Galectin-9 is a ligand for HAVCR2/TIM3 and induces T-helper type 1 lymphocyte (Th1) death. In addition, Galectin-9 suppresses tumor cell metastasis by interfering with the associations CD44, VCAM-1, Integrin α4β1.