基因名：
LRP1
产品别名：
A2MR； APOER； APR； CD91； IGFBP-3R； IGFBP3R； IGFBP3R1； KPA； LRP； LRP1A； TGFBR5； LRP1； LDL receptor related protein 1； LDL receptor related protein 1； prolow-density lipoprotein receptor-related protein 1； TbetaR-V/LRP-1/IGFBP-3 receptor； alpha-2-macroglobulin receptor； apolipoprotein E receptor； low density lipoprotein receptor-related protein 1； type V tgf-beta receptor； 低密度脂蛋白受体相关蛋白1； 低密度脂蛋白受体相关蛋白1(LRP1)； 磷酸化低密度脂蛋白受体相关蛋白1；
背景信息：
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]
