基因名：
SMAD2
产品别名：
CHTD8； JV18； JV18-1； LDS6； MADH2； MADR2； hMAD-2； hSMAD2； SMAD2； SMAD family member 2； SMAD family member 2； mothers against decapentaplegic homolog 2； MAD homolog 2； SMAD, mothers against DPP homolog 2； Sma- and Mad-related protein 2； mother against DPP homolog 2； Smad同源物2(Smad2)； 磷酸化Smad2； 磷酸化细胞信号转导分子SMAD2； 磷酸化细胞信号转导分子SMAD2/SMAD3； 细胞信号转导分子Smad-2；
背景信息：
Mothers against decapentaplegic homolog 2(SMAD2) is a cytoplasm protein which belongs to the dwarfin/SMAD family. Smad proteins undergo rapid nuclear translocation upon stimulation by transforming growth factor and in so doing transduce the signal into the nucleus. Receptor-regulated SMAD is an intracellular signal transducer and transcriptional modulator activated by TGF-beta and activin type 1 receptor kinases. SMAD2 is contains 1 MH1 (MAD homology 1) domain and1 MH2 (MAD homology 2) domain. It is expressed at high levels in skeletal muscle, endothelial cells, heart and placenta. It binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. It may act as a tumor suppressor in colorectal carcinoma. And SMAD2 positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
