基因名：
MCAM
产品别名：
CD146； HEMCAM； METCAM； MUC18； MelCAM； MCAM； melanoma cell adhesion molecule； melanoma cell adhesion molecule； cell surface glycoprotein MUC18； Gicerin； S-endo 1 endothelial-associated antigen； cell surface glycoprotein P1H12； melanoma adhesion molecule； melanoma-associated antigen A32； melanoma-associated antigen MUC18； CD146分子(CD146)； 磷酸化黑色素瘤细胞粘附分子CD146； 黑色素瘤细胞粘附分子CD146；
背景信息：
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
