基因名：
MCM7
产品别名：
CDC47； MCM2； P1.1-MCM3； P1CDC47； P85MCM； PNAS146； PPP1R104； MCM7； minichromosome maintenance complex component 7； minichromosome maintenance complex component 7； DNA replication licensing factor MCM7； CDC47 homolog； homolog of S. cerevisiae Cdc47； minichromosome maintenance deficient 7； protein phosphatase 1, regulatory subunit 104； 微小染色体维持缺陷蛋白7；
背景信息：
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
