基因名：
MDM2
产品别名：
ACTFS； HDMX； LSKB； hdm2； MDM2； MDM2 proto-oncogene； MDM2 proto-oncogene； E3 ubiquitin-protein ligase Mdm2； MDM2 oncogene, E3 ubiquitin protein ligase； MDM2 proto-oncogene, E3 ubiquitin protein ligase； Mdm2, p53 E3 ubiquitin protein ligase homolog； Mdm2, transformed 3T3 cell double minute 2, p53 binding protein； double minute 2, human homolog of; p53-binding protein； oncoprotein Mdm2； Mdm2 p53结合蛋白同源物(MDM2)； 双微体2癌基因； 磷酸化双微体2癌基因；
背景信息：
Inhibits TP53/p53- and TP73/p73-mediated cell cyclearrest and apoptosis by binding its transcriptional activation domain. Functions as a ubiquitin ligase E3, in the presence of E1 and E2, toward p53 and itself. Permits the nuclear export of p53 and targets it for proteasome-mediated proteolysis. Binds p53, p73, ARF(P14), ribosomal protein L5 and specifically to RNA. Can interact also with retinoblastoma protein(RB), E1A-associated protein EP300 and the E2F1 transcription factor. Forms a ternary complex with TP53/p53 and WWOX. Interacts with CDKN2AIP, MTBP, TRBG1 and USP7. Isoform Mdm2-F does not interact with TP53/p53. Interacts with PYHIN1. Interacts with, and ubiquitinates HIV-1 Tat. Belongs to the MDM2/MDM4 family.
