基因名：
MIA2
产品别名：
CTAGE5； MEA6； MGEA； MGEA11； MGEA6； TALI； MIA2； MIA SH3 domain ER export factor 2； MIA SH3 domain ER export factor 2； melanoma inhibitory activity protein 2； CTAGE family member 5, ER export factor； CTAGE family, member 5； MIA protein 2； TANGO1-like； cutaneous T-cell lymphoma-associated antigen 5； melanoma inhibitory activity 2； meningioma expressed antigen 6 (coiled-coil proline-rich)； meningioma-expressed antigen 6/11； protein cTAGE-5； 皮肤T细胞淋巴瘤相关抗原5； 黑色素瘤抑制活性蛋白2；
背景信息：
Cutaneous T cell lymphomas (CTCL) represent a group of malignancies that originate from CD4-T lymphocytes and manifest on the skin. CTCL is a general term for several neoplasms including mycosis fungoides, T cell leukemia/ lymphoma and pagetoid reticulosis, all of which are very difficult to treat in the advanced stages. CTAGE2 (cutaneous T cell lymphoma associated-antigen 2) is a member of the cancer/testis antigen family of proteins (CTAGE) that, under normal conditions, are found primarily in the testis with little or no expression in other parts of the body. Another member of the CTAG family, namely CTAGE5 (also known as MEA11, MEA6, MGEA11 or MGEA6), is a tumor associated antigen that is found in tumors of various origins, including cutaneous T cell lymphomas. Both CTAGE2 and CTAGE5 are expressed as multiple isoforms due to alternative splicing events.
