基因名：
AFF1
产品别名：
AF4； FEL； MLLT2； PBM1； AFF1； ALF transcription elongation factor 1； ALF transcription elongation factor 1； AF4/FMR2 family member 1； ALL1-fused gene from chromosome 4 protein； KMT2A/AFF1 fusion protein； myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2； pre-B-cell monocytic leukemia partner 1； proto-oncogene AF4； AF4/FMR2家族成员1(AFF1)； 原癌基因AF4蛋白；
背景信息：
Proto-oncogene AF-4 (or FEL) is a product of a chromosomal aberration of the human gene AFF1, which is associated with acute leukemias. The fusion of AF-4 on chromosome band 4q21 with the mixed lineage leukemia (MLL or HRX) gene on 11q23 results in a MLL-AF-4 chimeric transcription factor in which AF-4 contributes transcriptional effector properties and requires cell-specific accessory factors. MLL is involved in several chromosomal translocations associated with acute myeloid and lymphoid leukemia. The MLL-AF-4 fusion protein is expressed in all normal hematopoietic cells. The expression of MLL-AF-4 influences the production of protein cyclin-dependent kinase inhibitor (CDKN1B), suggesting that inhibition of MLL-AF-4 expression may be a powerful and highly specific treatment of chemotherapy-resistant leukemia.
