基因名：
MPL
产品别名：
C-MPL； CD110； MPLV； THCYT2； THPOR； TPOR； MPL； MPL proto-oncogene, thrombopoietin receptor； MPL proto-oncogene, thrombopoietin receptor； thrombopoietin receptor； TPO-R； myeloproliferative leukemia protein； myeloproliferative leukemia virus oncogene； proto-oncogene c-Mpl； 血小板生成素受体； 血小板生成素受体(TPOR)；
背景信息：
The c-mpl gene encodes a member of the hematopoietic cytokine receptor superfamily. This gene was discovered through the study of a murine retrovirus which induces an acute myeloproliferative syndrome in mice.MPLV (for myeloproliferative leukemia virus) has transduced a truncated and constitutively activated form of the c-mpl receptor chain. High levels of c-mpl expression were detected in 45% of acute myeloid leukemia (AML). No correlation was found between c-mpl expression and the French-American-British classification subtype of AML.
