基因名：
MRE11
产品别名：
ATLD； HNGS1； MRE11A； MRE11B； MRE11； MRE11 homolog, double strand break repair nuclease； MRE11 homolog, double strand break repair nuclease； double-strand break repair protein MRE11； AT-like disease； DNA recombination and repair protein； MRE11 double strand break repair nuclease A； MRE11 homolog 1； MRE11 homolog A, double strand break repair nuclease； MRE11 homolog, double strand break repair nuclease A； MRE11 meiotic recombination 11 homolog A； MRE11 meiotic recombination 11-like protein A； double-strand break repair protein MRE11A； endo/exonuclease Mre11； meiotic recombination 11 homolog 1； meiotic recombination 11 homolog A； DNA损伤关键蛋白Mre11； 磷酸化DNA损伤关键蛋白Mre11；
背景信息：
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
