基因名：
ABCC1
产品别名：
ABC29； ABCC； DFNA77； GS-X； MRP； MRP1； ABCC1； ATP binding cassette subfamily C member 1； ATP binding cassette subfamily C member 1； multidrug resistance-associated protein 1； ATP-binding cassette transporter variant ABCC1delta-ex13； ATP-binding cassette transporter variant ABCC1delta-ex13&14； ATP-binding cassette transporter variant ABCC1delta-ex25； ATP-binding cassette transporter variant ABCC1delta-ex25&26； ATP-binding cassette, sub-family C (CFTR/MRP), member 1； LTC4 transporter； glutathione S-conjugate export pump； glutathione-S-conjugate-translocating ATPase ABCC1； leukotriene C(4) transporter； 多药耐药关联蛋白1(MRP1)； 多药耐药相关蛋白1；
背景信息：
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]
